Technology That Drives Results
From a patient-facing mobile app to proprietary scientific tools like PCRS and TRANR, CenExel deploys cutting-edge technology across every stage of the clinical trial lifecycle — delivering superior data quality and operational excellence at scale.
30+
Global trials using CenExel's proprietary PCRS tool
18+
Centers of Excellence powered by our technology
2min
Average PCRS administration time per visit
100%
Patient recruitment target achievement rate
The Future of Trial Recruitment Is an App.
Your One-Stop Shop for Clinical Trials That Fit Your Life
Are you looking for new ways to manage your health or contribute to groundbreaking medical research? The CenExel Clinical Trials App is here to connect you with the latest and most relevant clinical trials tailored to your health needs! Designed for ease and convenience, our app makes it simple to find and join studies that can make a difference.
Join the Future of Medicine Today!
Start making a difference in your health today. Download the CenExel Clinical Trials App now!
PCRS
Placebo-Control Reminder Script
powered by PCRS
The PCRS is the only empirically-validated tool proven to significantly reduce placebo and nocebo effects in clinical trials — protecting signal detection and reducing the risk of trial failure.
A trained site rater reads the PCRS paragraph to each participant at every study visit, prior to administering the primary efficacy scale. The script systematically reviews expectation bias, placebo misunderstanding, misconceptions about site staff interactions, and subject role uncertainty.
After delivery, the rater assesses participant comprehension, ensuring consistent delivery across all visits and sites.
Before Every Efficacy Assessment
A trained site rater reads the PCRS paragraph to each participant at every study visit, prior to administering the primary efficacy scale.
Addresses Placebo Response Factors (PRFs)
The script systematically reviews expectation bias, placebo misunderstanding, misconceptions about site staff interactions, and subject role uncertainty.
Comprehension Confirmed
The rater assesses participant understanding of PCRS content, ensuring consistent delivery across all visits and sites.
Psychiatry
Depression (MDD)
Psychosis
Schizophrenia
General Medicine
CNS
How PCRS Works at Every Visit
01
Before Every Efficacy Assessment
A trained site rater reads the PCRS paragraph to each participant at every study visit, prior to administering the primary efficacy scale.
02
Addresses Placebo Response Factors
The script systematically reviews expectation bias, placebo misunderstanding, misconceptions about site staff interactions, and subject role uncertainty.
03
Comprehension Confirmed
The rater assesses participant understanding of PCRS content, ensuring consistent delivery across all visits and sites — every time.
TRANR
Immersive Standardization Software
Designed to Support Clinical Trials
- Structured participant calibration intended to address expectation-driven placebo response prior to dosing
- Standardized educational framework to promote consistent interpretation of pain and relief scales across sites without reliance on individual staff scripting
- Behavioral training components intended to reduce variability across 0-10 pain scales, categorical relief scales, and double stopwatch endpoints
- Reinforcement of consistent perceptible and meaningful relief reporting practices
TRANRTM is an immersive software application designed to reduce expectation-driven variability in subjective pain endpoints and support assay sensitivity across multi-site clinical trials. Standardized across sites and independent of individual staff instruction, the TRANR software promotes consistent participant understanding across study participation.
Delivered digitally at screening and randomization, the software uses competency-based progression to confirm comprehension and reinforce standardized endpoint interpretation across all sites.
The software is customizable to protocol-specific scales and endpoint structures.
Enhance Data Sensitivity By
Calibrating Pain Reporting
The Problem: Expectation-driven Placebo Response and Variability
Anticipating a positive outcome can trigger neurobiological processes that lead to genuine pain relief — a phenomenon known as the Placebo Effect
Variability arises from inconsistent understanding of how to use pain and relief scales to report subjective experience, introducing avoidable noise into the data
The Solution: Immersive
Standardization
TRANR™ is an immersive, interactive standardization tool designed to transform how participants approach pain studies—shifting their mindset from ‘people pleaser’ to ‘product tester’. All subjects, across every site, receive standardized training—ensuring consistency despite staff variability, and establishing the foundation for cleaner, more interpretable data.
- Research Staff
Research staff provide the applicable QR code to the participant.
- Scans the QR
- Software Application
- software progresses
If logical answers are received, the software progresses to the next concept. If illogical answers are chosen, the software provides further education and the participant may try again by selecting a new response.
USING THE TRANR SOFTWARE:
- Module 1 is completed at the screening visit:
- Module 2 is completed prior to surgery or randomization:
How it works: The virtual journey
Define the participant’s role:
Participants transition from a subordinate role as study subjects to active partners in research.
Explain the science :
Understanding concepts like blinding, randomization, and the “why” behind a placebo arm resets expectations.
Calibrate reporting:
Standardized training on the precise use of measurement scales enhances accuracy and reliability of data.
Demonstrate understanding:
The immersive program enables participants to practice skills, demonstrate understanding, and receive re‑training as needed.
Core curriculum: the PENTR method
Placebo
1. You may receive active product or placebo
2. Depending on what you receive, you may or may not have pain relief
Equally important:
On a study, positive and negative answers are equally important
Notice how you feel:
Your only job is to notice how you feel and reportthat to us
Time to absorb
It is important to give the test product enough time to absorb
Rescue medication:
1. Rescue is intended to be used when the test product is not working
2. Rescue is not harmful to study results if used appropriately